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乳腺癌:基质就是信息 Breast Cancer:The Matrix Is the Message

已有 120 次阅读2021-1-27 16:53 |个人分类:TET学习|系统分类:医学科学| 乳腺癌

乳腺癌:基质就是信息.Breast Cancer:The Matrix Is the Message
病理学家描述了乳腺癌标本的许多方面,但很少关注间质。虽然有些肿瘤的间质比其他肿瘤多,但结缔组织增生只是导管癌的许多特性之一。病理学评估应该确定与肿瘤快速进展相关的危险因素,这似乎是合乎逻辑的;然而,病理学家关注的是更实际的问题:肿瘤的范围、组织学亚型的分类以及确定治疗干预的特性,如雌激素的表达受体(ER)或HER2/neu。
Pathologists characterize many aspects of breast cancer specimens but rarely pay much attention to the stroma. Whereas some tumors have more stroma than others, desmoplasia is only one of many properties that vary among individual ductal carcinomas. It seems logical that the pathology assessment should identify risk factors associated with rapid tumor progression; however, the pathologist focuses on issues that are more pragmatic: the extent of tumor, classification into histologic subtypes, and identification of properties that define therapeutic intervention, such as e.xpression of estrogen receptor (ER) or HER2/neu. 

图1.浸润性导管癌中具有致密纤维间质的类似TACS-2和TACS-3的间质模式(TACS-2,散在围绕在癌灶周围)。A:TACS-2样间质同心围绕癌细胞群,表明肿瘤细胞控制了其形成。B:一些肿瘤细胞散布在致密胶原束之间;其他肿瘤细胞破坏了胶原纤维束。与TACS-3一致,这一模式提示浸润到已存在的间质。(TACS-3,致密笔直的胶原纤维束穿过癌灶,肿瘤细胞沿于胶原纤维走行分布。)比例尺=50μm。

Figure 1. Stromal patterns resembling TACS-2 and TACS-3 in invasive ductal cancers with dense fibrous stroma. A:  The  The TACS-2 -l.i.k.e stroma organizes concentrically around the cancer cell groups, suggesting that the tumor cells have controlled its formation.B: Some tumor cells are interspersed between bundles of dense collagen; other tumor cells disrupt the bundles. Consistent with TACS-3, this pattern suggests invasion into a pre-formed stroma. Scale bars = 50 μm.


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回复 hyc3140 2021-1-27 17:05
Locker J, Segall JE. Breast cancer: the matrix is the message[J]. The American journal of pathology, 2011,178:966-968.

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