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国际癌症胸腺上皮肿瘤分期研究协会项目：即将发布（第九版）恶性肿瘤TNM分类的T成分建 ...

已有 2889 次阅读2023-10-10 12:03 |个人分类:TET学习|系统分类:医学科学| 胸腺上皮肿瘤, TNM

国际癌症胸腺上皮肿瘤分期研究协会项目：即将发布（第九版）恶性肿瘤TNM分类的T成分建议

The International Association for the Study of Lung Cancer Thymic Epithelial Tumor Staging Project: Proposal for the T Component for the Forthcoming (Ninth) Edition of the TNM Classification of Malignant Tumors

引言：第八版恶性肿瘤分期分类采用了基于TNM的胸腺上皮肿瘤分期分类系统。国际癌症研究协会分期和预后因素委员会胸腺领域开发了一个新的数据库，旨在为第九版分期分类系统提出建议。本文概述了第九版胸腺恶性肿瘤TNM分期分类中T类的拟议定义。

方法：收集11347例胸腺上皮肿瘤患者的全球集体数据库。对9147名有可用生存数据的患者进行了分析。总生存率、无复发率和累积复发发生率被用作结果指标。分别对胸腺瘤、胸腺癌和胸腺神经内分泌肿瘤进行分析。

结果：对T型的建议包括：T1型分为T1a（≤5cm）和T1b（>5cm），与纵隔胸膜侵犯无关；T2包括心包、肺或膈神经的直接侵犯；T3表示直接侵犯头臂静脉、上腔静脉、胸壁或心外肺动脉和静脉；T4类别与第八版分类相同，涉及主动脉和主动脉弓血管、心包内肺动脉和静脉、心肌、气管或食道的直接侵犯。

结论：第九版TNM分类中提出的T分类为胸腺上皮肿瘤基于TNM的分期系统的T成分的结果提供了良好的区分。

Introduction: A TNM-based stage classification system of thymic epithelial tumors was adopted for the eighth edition of the stage classification of malignant tumors. The Thymic Domain of the Staging and Prognostics Factor Committee of the International Association for the Study of Lung Cancer developed a new database with the purpose to make proposals for the ninth edition stage classification system. This article outlines the proposed definitions for the T categories for the ninth edition TNM stage classification of thymic malignancies.

Methods: A worldwide collective database of 11,347 patients with thymic epithelial tumors was assembled. Analysis was performed on 9147 patients with available survival data. Overall survival, freedom-from-recurrence, and cumulative incidence of recurrence were used as outcome measures. Analysis was performed separately for thymomas, thymic carcinomas, and neuroendocrine thymic tumors.

Results: Proposals for the T categories include the following: T1 category is divided into T1a (≤5 cm) and T1b (>5 cm), irrespective of mediastinal pleura invasion; T2 includes direct invasion of the pericardium, lung, or phrenic nerve; T3 denotes direct invasion of the brachiocephalic vein, superior vena cava, chest wall, or extrapericardial pulmonary arteries and veins; and T4 category remains the same as in the eighth edition classification, involving direct invasion of the aorta and arch vessels, intrapericardial pulmonary arteries and veins, myocardium, trachea, or esophagus.

Conclusions: The proposed T categories for the ninth edition of the TNM classification provide good discrimination in outcome for the T component of the TNM-based stage system of thymic epithelial tumors.

引用：Okumura M, Marino M, Cilento V, Goren E, Ruffini E, Dibaba D, Ahmad U, Appel S, Bille A, Boubia S, Brambilla C, Cangir AK, Detterbeck F, Falkson C, Fang W, Filosso PL, Giaccone G, Girard N, Guerrera F, Huang J, Infante M, Kim DK, Lucchi M, Marom EM, Nicholson AG, Rami-Porta R, Rimner A, Simone CB 2nd, Asamura H; Members of the International Association for the Study of Lung Cancer Staging and Prognostic Factors Committee and of the Advisory Boards and Participating Institutions. The International Association for the Study of Lung Cancer Thymic Epithelial Tumor Staging Project: Proposal for the T Component for the Forthcoming (Ninth) Edition of the TNM Classification of Malignant Tumors. J Thorac Oncol. 2023 Aug 25:S1556-0864(23)00751-7. doi: 10.1016/j.jtho.2023.08.024. Epub ahead of print. PMID: 37634808.

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hyc3140

国际癌症胸腺上皮肿瘤分期研究协会项目：即将发布（第九版）恶性肿瘤TNM分类的T成分建 ...

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