肿瘤倍增时间是预测胸腺上皮肿瘤的组织学类型的有用参数

PURPOSE:

We assessed the utility of the tumor doubling time (TDT) for predicting the histological type of thymic epithelial tumors.

我们评估了肿瘤倍增时间（TDT）用于预测胸腺上皮肿瘤的组织学类型的应用价值。

METHODS:

We retrospectively reviewed 130 patients with thymic epithelial tumors who underwent computed tomography two or more times before surgery. The patients were divided into low-risk thymoma (types A, AB and B1), high-risk thymoma (types B2 and B3) and thymic carcinoma (thymic carcinoma and thymic neuroendocrine tumor) groups. In the 96 patients who showed tumor enlargement, the relationship between the histological type and the TDT of the tumor was investigated.

我们回顾性分析了130例胸腺上皮肿瘤患者，这些患者在手术前接受过两次或两次以上的CT扫描。 患者分为低危胸腺瘤（A型，AB型和B1型）、高危胸腺瘤（B2型和B3型）和胸腺癌（胸腺癌和胸腺神经内分泌肿瘤）。 在显示肿瘤增大的96名患者中，分析了组织学类型与肿瘤TDT之间的关系。

RESULTS:

The study population included 55 men and 41 women from 26 to 82 years of age. The TDT of the thymic carcinoma group (median 205 days) was significantly shorter in comparison to the low-risk thymoma (median 607 days) and high-risk thymoma (median 459 days) groups. No significant differences were observed between the low-risk thymoma and high-risk thymoma groups. When we set the cutoff time for differentiating thymic carcinoma group from thymoma at 313 days, the sensitivity and specificity were 83.8% and 82.1%, respectively.

研究人群包括55名男性和41名26至82岁的女性。 与低危胸腺瘤（中位数607天）和高危胸腺瘤（中位数459天）组相比，胸腺癌组的TDT（中位数205天）显著缩短。 低危胸腺瘤和高危胸腺瘤组之间未观察到显著差异。当我们设定截断时间为313天来区分胸腺癌组与胸腺瘤时，其敏感性和特异性分别为83.8％和82.1％。

CONCLUSIONS:

The TDT is a useful parameter for differentiating between thymoma and thymic carcinoma group.

TDT是鉴别胸腺瘤和胸腺癌的有用参数。

KEYWORDS:

Computed tomography; Histological type; Thymic epithelial tumors; Tumor doubling time

Fukumoto K, et al. The tumor doubling time is a useful parameter for predicting the histological type of thymic epithelial tumors. Surg Today. 2019 May 27. doi: 10.1007/s00595-019-01822-9. [Epub ahead of print] PubMed PMID: 31134370.