胸腺上皮性肿瘤组织学与新TNM分期系统的预后意义和关系

BACKGROUND:

 This study aims to describe the relationship between the new tumor nodes metastasis (TNM) staging and World Health Organization (WHO) classification and to identify how these two variables relate to each other and whether they possess a prognostic value in predicting survival and recurrence of disease.

本研究旨在描述新版肿瘤淋巴结转移（TNM）分期与世界卫生组织（WHO）分类之间的关系，并确定这两个变量间的相关性，以及它们是否具有预测疾病生存和复发的预后价值。

METHODS:

 Medical records of 54 patients who underwent surgery for thymic epithelial tumors between 1996 and 2015 were reviewed.The histologic type of neoplasm was classified according to the criteria of WHO and staging was evaluated using the new TNM classification system.

回顾了1996年至2015年间接受手术治疗的54例胸腺上皮肿瘤患者的病历资料。根据WHO标准对肿瘤的组织学类型进行分类，并使用新的TNM分类系统评估分期。

RESULTS:

 A significant correlation between the TNM stages and the histological classification was found (p < 0.001). Complete resection is related to both TNM stage and histological grading (p < 0.001). Evaluation of the 5- and 10-year survival curves shows how these are significantly correlated only at the stage (p = 0.03 and = 0.04, respectively). The risk of death at 5 and 10 years for stages III to IV is six and three times higher than in stages I to II, respectively. Regarding the disease-free survival, there is significant correlation with both staging and histology (p = 0.001 and = 0.02, respectively).

发现TNM分期与组织学分类之间存在显著相关性（p <0.001）。 完全切除与TNM分期和组织学分级相关（p <0.001）。 5年和10年生存曲线的评估显示这些仅在分期（分别为p = 0.03和= 0.04）存在显著相关。  III至 IV期的5年和10年死亡风险分别比 I至II期高六至三倍。 关于无病生存，与分期和组织学显著相关（p值分别为 0.001和 0.02）。

CONCLUSIONS:

 There is a significant correlation between the new TNM staging and the histological grade WHO. The ability to implement a complete resection, the overall and disease-free survival is closely related to the thymoma stage. Furthermore, both histotype and stage correlate with disease-free survival. In fact, the least aggressive stages, both WHO and TNM, have a free time out of disease superior to advanced stages.

Fig. 1 Histogram representing the relationship between tumor nodes metastasis (TNM) stages and World Health Organization (WHO) types.

图1 肿瘤淋巴结转移（TNM）分期与世界卫生组织（WHO）分类间关系的直方图