2021年11月,Science发表了来自耶鲁大学科学家们题为“The spectrum of inflammatory responses”的综述。这篇论文通过总结关于炎症的研究,提出了一个观点:炎症反应是机体基本反应,并非是简单地针对病理情况下一种防御性机制。当机体偏离稳态,即使并非病理状态,炎症反应就会发生。相对于生理学发展,对于炎症的认识亟待提高。
Inflammation is an integral part of animal biology. It provides critical protection from adverse environmental factors by enforcing the defense of homeostasis and the functional and structural integrity of tissues and organs. Recent advances have uncovered a broad range of biological processes that involve inflammatory control, calling for a renewed framework of inflammation beyond its classical roles in defense from infection and injury. In this Review, new perspectives on inflammation biology are discussed and new research directions are suggested to address the fundamental gaps in our current understanding.