磁共振T2 加权和DWI图像的定量直方图分析预测恶性胸腺上...

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磁共振T2 加权和DWI图像的定量直方图分析预测恶性胸腺上皮肿瘤
Quantitative Histogram Analysis of T2-Weighted and Diffusion-Weighted Magnetic Resonance Images for Prediction of Malignant Thymic Epithelial Tumors

目的：评估 T2 加权图像和表观扩散系数 (ADC) 直方图分析区分高危胸腺上皮肿瘤 (TET) 和低危 TET 的价值。
方法：本研究招募了 49 名胸腺切除术后组织病理学证实为 TET 的患者，并回顾性地将其分为低危 TET（低危胸腺瘤）或高危 TET（高危胸腺瘤或胸腺癌）。从定量直方图分析中获得了十二个参数。使用 Mann-Whitney U 检验比较直方图参数。通过受试者操作特征曲线分析估计诊断效力。
结果：25 名患者被归类为低危 TET，24 名患者被归类为高危 TET。平均 ADC 值显示出区分高危 TET 和低危 TET 的诊断功效，曲线下面积为 0.7，优于单独使用传统方法时。
结论：基于 ADC 的直方图分析有助于区分高风险和低风险 TET。

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Abstract
Purpose: To assess the value of histogram analysis for differentiating a high-risk thymic epithelial tumor (TET) from a low-risk TET using T2-weighted images and the apparent diffusion coefficient (ADC).
Methods: Forty-nine patients with histopathologically proven TET after thymectomy were enrolled in this study and retrospectively classified as having low-risk TET (low-risk thymoma) or high-risk TET (high-risk thymoma or thymic carcinoma). Twelve parameters were obtained from the quantitative histogram analysis. The histogram parameters were compared using the Mann-Whitney U test. Diagnostic efficacy was estimated by receiver-operating characteristic curve analysis.
Results: Twenty-five patients were classified as having low-risk TET and 24 as having high-risk TET. The mean ADC value showed diagnostic efficacy for differentiating high-risk TET from low-risk TET, with an area under the curve of 0.7, and was better than when using conventional methods alone.
Conclusion: The ADC-based histogram analysis could help to differentiate between high-risk and low-risk TETs.


Morikawa K, Igarashi T, Shiraishi M, Kano R, Misumi S, Ojiri H, Asano H. Quantitative Histogram Analysis of T2-Weighted and Diffusion-Weighted Magnetic Resonance Images for Prediction of Malignant Thymic Epithelial Tumors. J Comput Assist Tomogr. 2021 Aug 2. doi: 10.1097/RCT.0000000000001197. Epub ahead of print. PMID: 34347704.

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